Professor Smalley was a villain who appeared in 'Reign of the Superman', the original Superman story. In the story, he was responsible for the creation of the Superman.

His experiments involved the usage of a strange mineral rock on his test subjects, one of whom became The Superman upon exposure to the rock.

Later in the story, Smalley attempted to use some of the substance on himself, to become a Superman as well; However, he was attacked and killed by The Superman.